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. 2017 Sep 4;45(18):10920. doi: 10.1093/nar/gkx806

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

Ying-Ren Wang 1, Shin-Fu Chen 1, Chyuan-Chuan Wu 2, Yi-Wen Liao 1, Te-Sheng Lin 1, Ko-Ting Liu 1, Yi-Song Chen 3, Tsai-Kun Li 3,4,*, Tun-Cheng Chien 5,*, Nei-Li Chan 1,6,*
PMCID: PMC5737763  PMID: 28977544

Nucleic Acids Res (2017). https://doi.org/10.1093/nar/gkx742

The authors wish to make the following correction to their article:

The chemical structure of etoposide shown in Figure 1 is incorrect. An oxygen atom is mistakenly shown as a carbon atom. A new Figure 1 is provided below and the figure has been updated in the published article.

Figure 1.

Figure 1.

Chemical structures of etoposide and the two etoplatins synthesized in this study. The polycyclic aglycone (rings A–D) and pendant ring (E-ring) of etoposide are labeled. A cis-dichlorodiammineplatinum(II) moiety was introduced via an amide linkage to the C4 position of the aglycone core in α and β configuration about the E-ring to produce etoplatin-N2α and N2β, respectively. Both etoplatins contain an additional chiral center (marked with asterisks) whose chirality was not specified during synthesis.


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