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. 2017 Dec 20;25:25. doi: 10.1186/s40199-017-0191-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The effect of OGD, sesamol, or S-NLCs on LDH release. S-NLCs effectively prevented the enhancement of LDH release after both 1-h (a) and 8-h OGD (b) that was reversed due to the pre-treatment with LY294002 (50 μM). Data are presented as the mean ± SEM of six independent experiments. ^{a, e} P < 0.001, and ^b P < 0.01 vs. the control, ^{c, d} P < 0.01 vs. OGD and OGD+ vehicle, ^f P < 0.05 vs. control and P < 0.001 vs. OGD and OGD + vehicle. (LDH: lactate dehydrogenase, OGD: oxygen-glucose deprivation, LY: LY294002, S-NLCs: sesamol-loaded nanostructured lipid carriers)