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. 2017 Dec 20;25:25. doi: 10.1186/s40199-017-0191-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — The brain delivery of S-NLCs. a: The presence of coumarin-6-loaded S-NLCs in the hippocampus which is one of the most vulnerable brain regions in the ischemic stroke (scale bar: 500 μm), b: Brain distribution study shows that S-NLCs provide significantly higher concentrations of sesamol in the brain. ^a P < 0.001, ^b P < 0.01, and ^c P < 0.05 vs. sesamol-treated group. (S-NLCs: sesamol-loaded nanostructured lipid carriers)