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. 2017 Nov 18;8(63):106511–106526. doi: 10.18632/oncotarget.22490

Figure 10. Snapshots of initiation and conduction of re-entry in the 2D slice model of human ventricles.

Figure 10

(A) In the WT condition, a conditioning wave generated by an S1 stimulus. Application of a premature S2 stimulus into the refractory and partially recovered region of an excitation wave after a delay of 340 ms. Snapshots at time = 2 ms (i), 170 ms (ii), 340 ms (iii), 850 ms (iv), and 1800 ms (v). (B) In the WT-D172N condition, a re-entry was initiated and maintained. Snapshots at time = 2 ms (i), 170 ms (ii), 310 ms (iii), 850 ms (iv), and 1800 ms (v). (C) In the WT-D172N + 3 µM CQ condition, a re-entry terminated. Snapshots at time = 2 ms (i), 170 ms (ii), 340 ms (iii), 850 ms (iv), and 1800 ms (v). Re-entrant wave self-terminated in the WT condition before this recording point but persisted in the WT-D172N condition. CQ eliminated the wavelets and terminated the re-entrant wave.