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. 2017 Nov 1;8(63):106778–106789. doi: 10.18632/oncotarget.22269

Figure 3. Impact of sex and smoking status on levels of estrogen metabolites.

Figure 3

(A) Comparison of estrogen metabolites in normal lung tissue from women vs. men. (B) Comparison of 4-OHEs and 2-OHEs in normal lung tissue, lung tumors and urine from women with NSCLC who are never-smokers (NS) or current-smokers (CS). Box plots denote the median and the 75th and 25th percentiles (inter-quartile range, IQR). The “whiskers” represent the most extreme points (≤ 1.5 times the IQR). Outliers are outside the box. P values are based on the Wilcoxon rank sum test (**P < 0.01).