. 2017 Nov 1;8(63):106778–106789. doi: 10.18632/oncotarget.22269

Table 2. Levels of estrogen and its metabolites in never- vs. current-smoking women*.

	Normal (pg/g tissue)				Tumor (pg/g tissue)				Urine (pg/mg creatinine)
	N n = 9	C n = 9	P N vs. C	FDR	N n = 8	C n = 9	P N vs. C	FDR	N n = 3	C n = 4	P N vs. C	FDR
E₁	6.85	10.32	0.340	0.402	8.77	12.02	0.074	0.242	24.97	32.70	0.857	1.000
E₂	13.11	18.19	0.190	0.275	18.73	24.36	0.200	0.371	8.24	12.75	0.857	1.000
E₃	3.02	4.93	0.077	0.167	4.22	5.18	0.200	0.371	20.85	28.02	1.000	1.000
2OHE₁	2.32	2.97	0.094	0.174	3.43	4.76	0.139	0.361	32.42	60.74	1.000	1.000
2OHE₂	1.04	2.16	0.004	0.017	1.23	2.47	0.021	0.234	13.56	43.25	0.628	1.000
4OHE₁	0.30	0.45	0.050	0.131	0.69	0.70	0.321	0.418	5.57	22.11	0.114	0.743
4OHE₂	0.12	0.35	0.001	0.008	0.17	0.42	0.036	0.234	1.94	11.58	0.057	0.495
2OME₁	1.38	1.55	0.297	0.386	1.73	1.73	0.815	0.883	7.64	11.05	0.400	1.000
2OME₂	0.85	0.92	0.387	0.419	1.37	1.13	0.673	0.795	1.89	2.59	0.400	1.000
2OHEs/Total	0.10	0.12	0.162	0.262	0.12	0.11	1.000	1.000	0.40	0.37	0.400	1.000
4OHEs/Total	0.01	0.02	0.006	0.018	0.02	0.02	0.277	0.400	0.06	0.18	0.057	0.371
2OMEs/Total	0.06	0.09	1.000	1.000	0.07	0.06	0.236	0.383	0.08	0.07	1.000	1.000
4OHEs/2OHEs	0.11	0.17	0.001	0.008	0.14	0.21	0.059	0.242	0.15	0.52	0.057	0.371

^*Values represent the medians. Statistical comparisons were based on the Wilcoxon rank sum test, with P ≤ 0.05 considered significant (underlines above as indicated). Bold highlight denotes FDR values ≤ 0.05. N: never smokers; C: current smokers.