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. 2017 Nov 6;8(63):107076–107088. doi: 10.18632/oncotarget.22328

Figure 2. ALS induces apoptosis and autophagy in A375 and skmel-5 cells through inhibition of the p38 MAPK signaling pathway.

Figure 2

(A) Flow cytometry analysis of apoptosis in A375 and skmel-5 cells after treatment with ALS at concentrations ranging from 0 to 5 μM for 24 hours; (B) Flow cytometry analysis of autophagy in A375 and skmel-5 cells after treatment with ALS at concentrations ranging from 0 to 5 μM for 24 hours; (C) Quantification of apoptotic A375 and skmel-5 cells after treatment with AL; (D) Quantification of autophagic A375 and skmel-5 cells after treatment with ALS; (E) Western blot analysis of the levels of p38 MAPK signaling pathway components in A375 and skmel-5 cells after treatment with ALS at concentrations ranging from 0 to 5 μM; (F) Quantification of relative protein levels. Data are expressed as the means ± SD. All experiments were repeated at least three times. (*p < 0.05, **p < 0.01, ***p < 0.001).