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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Transplantation. 2018 Jan;102(1):59–69. doi: 10.1097/TP.0000000000001902

Figure 1.

Figure 1

Survival of fully mismatched skin grafts following administration of Rapamycin; recipient splenic cell counts and CD4+/CD8+ T cell frequencies. (A) Skin allografts from young DBA mice were transplanted onto young or old C57BL/6 mice. Recipients received daily intraperitoneal injections of either control solution (PBS) or Rapamycin and graft survival was monitored daily (n=7-12 animals/group). (B) Spleens were collected by day 7 after transplantation and single cell suspensions of splenocytes were obtained. Total cell count was determined and frequencies of CD4+ and CD8+ T cells were assessed using flow cytometry (n=5-6 animals/group). Log-rank test was used to compare graft survival; data represent mean ± SD; *, p<0.05; **, p<0.01; ***, p<0.001.