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. 2018 Jan 1;8(1):45–60. doi: 10.7150/thno.20885

Figure 3.

Figure 3

In vivo serial imaging of carotid plaques in ApoE-/- mice. (A) Schematic of the serial imaging of carotid plaques in ApoE-/- mice. (B) Schematic illustration of multi-channel confocal intravital fluorescence microscopy. Representative in vivo optical imaging of carotid plaques at baseline and after treatment in the MMR-Lobe (C), lobeglitazone per se (D), MMR vehicle (E) and control groups (F). Vessel angiograms obtained from the fluorescein isothiocyanate (FITC)-dextran channel clearly identified the plaques. Macrophage contents within the plaques were imaged using the cyanine 5.5 channel. The plaque burden and macrophage signals markedly decreased over the 4 weeks of treatment in MMR-Lobe-treated mice as compared to the other groups. Arrows indicate carotid bifurcation.