Takashi K Ito
Takashi K Ito
1Department of Pathology, University of Washington, Seattle, WA, United States
2Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan
3International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
1,2,3,*,
Chenhao Lu
Chenhao Lu
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Jacob Khan
Jacob Khan
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Quy Nguyen
Quy Nguyen
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Heather Z Huang
Heather Z Huang
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Dayae Kim
Dayae Kim
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
James J Phillips
James J Phillips
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Jo Tan
Jo Tan
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Yenna Lee
Yenna Lee
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Tuyet Nguyen
Tuyet Nguyen
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Samy Khessib
Samy Khessib
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Natalie Lim
Natalie Lim
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Surapat Mekvanich
Surapat Mekvanich
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Joshua Oh
Joshua Oh
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Victor V Pineda
Victor V Pineda
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Weirong Wang
Weirong Wang
1Department of Pathology, University of Washington, Seattle, WA, United States
4Research Institute of Atherosclerotic Disease, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, China
5Laboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, China
1,4,5,
Alessandro Bitto
Alessandro Bitto
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
Jonathan Y An
Jonathan Y An
1Department of Pathology, University of Washington, Seattle, WA, United States
1,
John F Morton
John F Morton
6Department of Comparative Medicine, University of Washington, Seattle, WA, United States
6,
Mitsutoshi Setou
Mitsutoshi Setou
2Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan
3International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
2,3,
Warren C Ladiges
Warren C Ladiges
6Department of Comparative Medicine, University of Washington, Seattle, WA, United States
6,
Matt Kaeberlein
Matt Kaeberlein
1Department of Pathology, University of Washington, Seattle, WA, United States
1,*
1Department of Pathology, University of Washington, Seattle, WA, United States
2Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Japan
3International Mass Imaging Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
4Research Institute of Atherosclerotic Disease, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, China
5Laboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an, China
6Department of Comparative Medicine, University of Washington, Seattle, WA, United States
Edited and reviewed by: Elena G. Pasyukova, Institute of Molecular Genetics (RAS), Russia
✉*Correspondence: Takashi K. Ito itotk777@hama-med.ac.jp
*Matt Kaeberlein kaeber@uw.edu
This article was submitted to Genetics of Aging, a section of the journal Frontiers in Genetics
Received 2017 Dec 2; Accepted 2017 Dec 6; Collection date 2017.
Keywords: S6K1, mTORC1, liver, lifespan, mitochondrial disease
Copyright © 2017 Ito, Lu, Khan, Nguyen, Huang, Kim, Phillips, Tan, Lee, Nguyen, Khessib, Lim, Mekvanich, Oh, Pineda, Wang, Bitto, An, Morton, Setou, Ladiges and Kaeberlein.
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