Table 1.
Mutations analyzed in the C-terminal domains of reverse transcriptase covering the connection (CN) and RNase H (RH) subdomains and the respective classes of antiretrovirals associated with resistance as described in the literature *.
| Subdomain | Mutation | ARV Class Associated with Resistance |
|---|---|---|
| CN | E312Q | NRTI |
| Y318F/W | NNRTI | |
| G335D/C (polymorphism) | NRTI | |
| N348I | NRTI and NNRTI | |
| A360I/V | NRTI | |
| V365I | NRTI | |
| T369I/V | NRTI and NNRTI | |
| A371V | NRTI | |
| A376S | NRTI and NNRTI | |
| E399D/G | NRTI and NNRTI | |
| A400T (polymorphism) | NRTI | |
| RH | D488E | NRTI |
| Q509L | NRTI and NNRTI | |
| Q547K | NRTI |