Table 6. Stratified analyses between MTHFR rs4845882 G>A polymorphism and NSCLC risk by sex, age, BMI, smoking status and alcohol consumption.

Variable	MTHFR rs4845882 G>A (case/control)a			Adjusted ORb (95% CI); P
	GG	GA	AA	GG	GA	AA	GA /AA	AA vs. (GA/GG)
Sex
Male	177/349	94/212	16/26	1.00	0.87 (0.63–1.21);P: 0.411	1.42 (0.71–2.85);P: 0.322	0.93 (0.68–1.26);P: 0.627	1.49 (0.75–2.96);P: 0.254
Female	132/283	97/142	5/17	1.00	1.47 (1.05–2.05);P: 0.025	0.68 (0.24–1.90);P: 0.460	1.39 (1.00–1.93);P: 0.051	0.59 (0.21–1.63);P: 0.304
Age
<60	136/286	92/169	10/20	1.00	1.17 (0.83–1.65);P: 0.361	1.15 (0.50–2.61);P: 0.746	1.17 (0.84–1.63);P: 0.359	1.08 (0.48–2.42);P: 0.862
≥60	173/346	99/185	11/23	1.00	1.07 (0.78–1.47);P: 0.685	1.12 (0.52–2.43);P: 0.777	1.07 (0.79–1.46);P: 0.653	1.09 (0.51–2.35);P: 0.820
Smoking status
Never	186/510	119/282	12/35	1.00	1.16 (0.88–1.53);P: 0.301	1.09 (0.54–2.18);P: 0.815	1.15 (0.88–1.51);P: 0.313	1.03 (0.52–2.04);P: 0.940
Ever	123/122	72/72	9/8	1.00	1.02 (0.68–1.55);P: 0.914	1.21 (0.45–3.27);P: 0.705	1.04 (0.70–1.56);P: 0.842	1.20 (0.45–3.20);P: 0.714
Alcohol consumption
Never	260/581	168/327	16/40	1.00	1.14 (0.89–1.45);P: 0.312	0.99 (0.53–1.85);P: 0.982	1.12 (0.88–1.42);P: 0.354	0.95 (0.51–1.75);P: 0.858
Ever	49/51	23/27	5/3	1.00	0.95 (0.47–1.92);P: 0.893	2.23 (0.47–10.67);P: 0.315	1.06 (0.54–2.08);P: 0.858	2.27 (0.48–10.64);P: 0.298
BMI (kg/m2)
< 24	207/338	120/190	10/18	1.00	1.06 (0.78–1.42);P: 0.724	1.03 (0.45–2.35);P: 0.952	1.05 (0.79–1.41);P: 0.737	1.00 (0.44–2.28);P: 0.992
≥ 24	102/294	71/164	11/25	1.00	1.24 (0.85–1.79);P: 0.262	1.26 (0.58–2.72);P: 0.557	1.24 (0.87–1.77);P: 0.236	1.16 (0.55–2.48);P: 0.697

^a The genotyping was successful in 521 (100.00%) NSCLC cases, and 1030 (99.90%) controls for MTHFR rs4845882 G>A;

^b Adjusted for age, sex, BMI, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model;