Table 2.

Scope of XtalFluor-E^® catalyzed synthesis of N,O-acetals.^a

Entry	Enamide	N,O-acetal	Yield (%)
1			95
2			98
3			98
4			95
5			80
6			40
7			98b
8			85
9			85c
10			98
11			91
12			72
13			60
14			98
15			71
			98d
16			83
17			86
18			98
19			98e
21			94
21			98d

^aReactions were performed at room temperature (0.1 mmol), reported yields are isolated unless otherwise indicated;

^b1.1 equivalents of nucleophile was used, requiring 48 h for reaction completion, resulting in the same yield;

^cReaction was performed at 1.0 mmol scale;

^dYield was determined by ¹H-NMR with methyl t-butyl ether as internal standard;

^eHFIP:methanol (9:1 v:v) was used as solvent.