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. 2017 Oct 30;7(2):e1386827. doi: 10.1080/2162402X.2017.1386827

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Figure 3. — Ex-vivo measurements of (TIL) or blood lymphocytes (BL) to kill autologous melanoma cells. Cytotoxicity presented at increasing effector to melanoma target cell ratios. Each figure is representative of 6 to 10 experiments (A) Comparing the same number of lymphocytes, TIL are more lytic than BL. TIL•, BL ▪. (B) TIL preferentially kill autologous melanoma cells as compared to allogeneic cells, consistent with MHC restriction. Pt C TIL•, Pt M TIL▪ (C) Killing is MHC restricted and not due to NK cells. Pt C BL •, Pt C BL minus NK ▪, Pt F BL ▴, Pt F BL minus NK ▾, (D) Depletion of CD8 T cells abrogates the killing. BL •, BL minus CD8 T▪ (E) Repeated injection in 3 patients of CKs mixed with irradiated autologous melanoma cells over many weeks increases the killing ex-vivo.