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. 2017 Dec 18;7(2):e1393599. doi: 10.1080/2162402X.2017.1393599

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Figure 7. — Immunosuppressive activity of CD14+HLA-DRlo monocytes from DLBCL patients. (A) CD8 T cell proliferation after 3 days stimulation of healthy donor (n = 8) or DLBCL patient (n = 6) PBMC with anti-CD3/CD28/4-1BB beads, with or without depletion of CD14+ monocytes. (B) Correlation of DLBCL patient CD14+ monocyte counts within the PBMC fraction versus the percentage increase in CD8 T cell proliferation after CD14+ monocyte depletion. (C) Proliferation of purified CD8 T cells from healthy donor PBMC (n = 18) following stimulation for 3 days with anti-CD3/CD28/4-1BB beads and co-culture with CD14+HLA-DRlo monocytes isolated from DLBCL patients PBMC, at the indicated ratios. (*p < 0.05; ** p < 0.01; *** p < 0.001)