Table 1. Clinical profiles of patients with HBV-ACLF in the derivation and validation cohorts.
| Parameters | Derivation cohort (n=211) | Validation cohort (n=94) | P values | ||
|---|---|---|---|---|---|
| Character | Age (years), mean±SD | 43.94±12.63 | 47.15±10.60 | 0.016* | |
| Male, n (%) | 176 (83.41) | 81(86.17) | 0.541 | ||
| Died within 30 days, n (%) | 54 (25.59) | 33 (35.11) | 0.089 | ||
| HE a | None HE, n (%) | 152 (72.04) | 61 (64.89) | 0.429 | |
| I-II HE, n (%) | 41 (19.43) | 24 (25.53) | |||
| III-IV HE, n (%) | 18 (8.53) | 9 (9.57) | |||
| Pre-existing chronic liver diseaseb | Chronic hepatitis B, n (%) | 167(79.15) | 49(52.13) | <0.001* | |
| Compensated liver cirrhosis, n (%) | 44 (20.85) | 45 (47.87) | |||
| In-hospital complication | Ascites | None, n (%) | 67 (31.75) | 26 (27.66) | 0.184 |
| Mild, n (%) | 78 (36.97) | 27 (28.72) | |||
| Moderate, n (%) | 47 (22.27) | 27 (28.72) | |||
| Severe, n (%) | 19 (9.00) | 14 (14.89) | |||
| Infection, n (%) | 12 (5.68) | 28 (29.78) | <0.001* | ||
| Suspicion of infection, n(%)c | 77 (36.49) | 19 (20.21) | 0.005* | ||
| Laboratory parameters at baseline | ALT (U/L), median (range) | 163.50 (13.70 -2550.00) |
197.75 (19.00 -7822.60) |
0.227 | |
| AST (U/L), median (range) | 161.35 (31.50 -5715.00) |
188.35 (21.00 -5688.20) |
0.118 | ||
| TBil (μmol/L), median (range) | 347.90 (171.93 -966.40) |
325.75 (172.50 -780.30) |
0.446 | ||
| INR, median (range) | 2.55 (1.08 -5.04) |
2.37 (1.32 -9.00) |
0.127 | ||
| Na (mmol/L), median (range) | 135.00 (111.00 -145.40) |
135.00 (113.50 -143.70) |
0.840 | ||
| Albumin(g/L), mean±SD | 31.00±4.73 | 31.25±4.51 | 0.667 | ||
| WBC (×109/L), median (range) | 7.01 (1.10 - 29.41) |
7.32 (1.11 -35.64) |
0.489 | ||
| Blood neutrophils percentage count, median (range) | 72.90 (26.60 -94.00) |
70.90 (46.90 -92.50) |
0.438 | ||
| Hemoglobin (g/L), mean±SD | 119.63±23.74 | 121.04±25.99 | 0.642 | ||
| PLT (×109/L), median (range) | 87.00 (9.00 -298.00) |
96.50 (26.00-297.00) |
0.077 | ||
| PTA, median (range) | 29.50 (8.00 -39.50) |
32.00 (9.00 -40.00) |
0.081 | ||
a Mild to moderate hepatic encephalopathy (HE) was defined as grade I or II HE, severe HE was defined as grade III or IV HE, according to the West Haven classification.
b The pre-existing chronic liver disease patients were divided into two groups, counter balanced between liver cirrhosis and chronic hepatitis B.
c Suspicion of infection based on at least one of the following: WBC count >10,000/mm3 or ≥50% increase with respect to baseline with a final value >8,000/mm3; more than 5% of band forms; and/or temperature >37.5°C.
* P<0.05.