Table 6. Stratified analyses between LEPR rs6588147 G>A polymorphism and ESCC risk by sex, age, BMI, smoking status and alcohol consumption.
| Variable | LEPR rs6588147 G>A (case/control)a | Adjusted ORb (95% CI); P | ||||||
|---|---|---|---|---|---|---|---|---|
| GG | GA | AA | GG | GA | AA | GA/AA | AA vs. (GA/GG) | |
| Sex | ||||||||
| Male | 267/769 | 94/290 | 14/19 | 1.00 | 0.89(0.67-1.20); P: 0.449 |
2.19(1.02-4.67); P: 0.044 |
0.97(0.73-1.29); P: 0.834 |
2.26(1.06-4.80); P: 0.035 |
| Female | 100/301 | 25/101 | 4/9 | 1.00 | 0.72(0.43-1.20); P: 0.204 |
1.19(0.34-4.22); P: 0.785 |
0.76(0.47-1.24); P: 0.274 |
1.29(0.37-4.55); P: 0.688 |
| Age | ||||||||
| <63 | 168/527 | 59/206 | 9/14 | 1.00 | 0.80(0.55-1.16); P: 0.233 |
2.58(1.00-6.62); P: 0.049 |
0.88(0.62-1.26); P: 0.484 |
2.71(1.06-6.91); P: 0.038 |
| ≥63 | 199/543 | 60/185 | 9/14 | 1.00 | 0.84(0.59-1.20); P: 0.339 |
1.40(0.58-3.39); P: 0.458 |
0.90(0.64-1.26); P: 0.534 |
1.48(0.61-3.56); P: 0.386 |
| Smoking status | ||||||||
| Never | 180/787 | 56/279 | 9/20 | 1.00 | 0.89(0.63-1.24); P: 0.486 |
1.88(0.82-4.31); P: 0.139 |
0.96(0.70-1.32); P: 0.807 |
1.94(0.85-4.44); P: 0.117 |
| Ever | 187/283 | 63/112 | 9/8 | 1.00 | 0.80(0.54-1.17); P: 0.248 |
2.00(0.71-5.66); P: 0.191 |
0.86(0.59-1.25); P: 0.438 |
2.12 (0.75-5.97); P: 0.155 |
| Alcohol consumption | ||||||||
| Never | 245/961 | 80/335 | 13/27 | 1.00 | 0.92(0.69-1.23); P: 0.590 |
1.69(0.84-3.40); P: 0.145 |
0.99(0.75-1.30); P: 0.944 |
1.73(0.86-3.47); P: 0.124 |
| Ever | 122/109 | 39/56 | 5/1 | 1.00 |
0.54(0.31-0.92); P: 0.024 |
5.03(0.48-52.46); P: 0.177 |
0.60(0.35-1.01); P: 0.056 |
5.79(0.56-59.52); P: 0.139 |
| BMI (kg/m2) | ||||||||
| <24 | 261/552 | 92/204 | 14/18 | 1.00 | 0.94(0.69-1.28); P: 0.700 |
1.79(0.84-3.82); P: 0.130 |
1.01(0.76-1.36); P: 0.936 |
1.83(0.86-3.89); P: 0.115 |
| ≥24 | 106/518 | 27/187 | 4/10 | 1.00 | 0.67(0.42-1.07); P: 0.093 |
1.96(0.59-6.59); P: 0.275 |
0.73(0.47-1.14); P: 0.168 |
2.14(0.64-7.17); P: 0.215 |
a For LEPR rs1137101 G>A, the genotyping was successful in 507 (99.41%) ESCC cases, and 1,496 (99.53%) controls.
b Adjusted for multiple comparisons [age, sex, BMI, smoking status and alcohol consumption (besides stratified factors accordingly)] in a logistic regression model.