Figure 2. Ugcg-deficient mice show delayed DEN-induced life threatening tumor burden.

(A), 8 months after DEN application small tumors of 1 to 2mm² occurred as indicated by red arrows; GB, gall bladder. (B), lower numbers of macroscopically detectable tumors on the liver surface were seen in GSL-deficient liver (^##, p<0.0075, Mann-Whitney test). (C and D), Ugcg^f/f controls suffering from tumor burden in the liver had to be sacrificed earlier than mice with Ugcg deficiency; ^*, p= 0.023 per group and p=0.050 per gender, by Cox-regression; n= 18 to 21 per genotype and gender. The tumor development occurred gender specific ∼15 weeks earlier in males (C) than in females (D).