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. 2017 Nov 29;8(65):109692–109702. doi: 10.18632/oncotarget.22766

Figure 3. Atsttrin reduced TNF-α-induced inflammatory cytokines in human nucleus.

Figure 3

(A) The immunohistochemistry of MMP-13, COX-2, iNOS and IL-17 in the human IVD tissues cultured TNF-α (50 ng/ml) in the presence or absence of Atsttrin (1 ug/ml) respectively. Scale bars=100 um. (B, C, D, E) Quantitative analysis of the positive area of MMP-13, COX-2, iNOS and IL-17 in different groups based on the result of immunohistochemical staining. The values are mean ± SEM of at least 3 independent experiments, *P<0.05, **P<0.01, ***P<0.001 VS control group. #P<0.05, ##P<0.01, ###P<0.001 VS TNF-α treatment group.