Table 2.

Biomarker-based therapy adjustment

Score	Corticosteroid dose step-wise adjustment	Follow-up
0	Reduce treatment 1 step	If score remains 0 on low-dose corticosteroid – type 2 (T2)-low severe asthma
1	Maintain current treatment	Adjust as necessary based on follow-up scores
2	Increase treatment 1 step	If score remains 2 despite maximal inhaled corticosteroid therapy necessitating systemic steroid therapy – T2-high severe asthma

All therapeutic adjustments will be automatically calculated and advised by the electronic case report form (e-CRF)

Corticosteroid treatment adjustment based on composite biomarker score