Table 1.

Pharmacological modulators of autophagy. Ref; reference, BRB; blood retinal barrier, BBB, blood brain barrier.

Compound	Source	Dosage	Effect/Mechanism	Used	Permeability
Rapamycin	EuromedexR-5000	100 nM	Autophagy inductor/mTOR kinase inhibitor	Ex vivo	Not tested
AZD8055	Axon, 1561	1 μM	Autophagy inductor/mTOR inhibitor	Ex vivo	Not tested
Bafilomycin A	Sigma, B1793	50 nM	Autophagy inhibitor/vacuolar ATPase inhibitor	Ex vivo	Not tested
3-Methyladenine	Sigma, M9281	10 mM	Autophagy inhibitor/PI3K type III inhibitor	Ex vivo	Not tested
Hydroxichloroquine	Lab.Rubió, 880872.4	30 μg/mL	Autophagy inhibitor/increases lysosomal pH	Ex vivo	Not tested
NH4Cl/Leupeptin	Sigma, A9434 Sigma, L2884	20 mM 100 mM	Autophagy inhibitor/increases lysosomal pH-proteases inhibitor	Ex vivo	Not tested
Leupeptin	Sigma, L2884	40 mg/kg	Autophagy inhibitor/proteases inhibitor	In vivo	BRB, not BBB