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. Author manuscript; available in PMC: 2019 Jan 30.
Published in final edited form as: Gene. 2017 Oct 21;641:220–225. doi: 10.1016/j.gene.2017.10.063

Fig. 6.

Fig. 6

Effect of modified U1 snRNA on Kv11.1 channel current in canonical poly(A) signal construct. (A) Representative currents recorded from Flp-In CV-1 cells stably expressing the full-length KCNH2 splicing-competent construct containing the canonical poly(A) signal following treatment with WT or modified U1 snRNA adenovirus (500 MOI) for 48 h. (B) I-V plot of tail current density measured at –50 mV following test voltages from –70 to +50 mV for WT (triangle, n=7) and modified U1 snRNA (3A>C/5U>A) (circle, n=8) adenoviruses.