There are errors in Table 3. Some of the arrows are missing in the published table. The publisher apologizes for this error. Please see the corrected Table 3 here.
Table 3. Phosphoproteins with different phosphopeptide abundance in the Cyp46a1-/- brain as compared to the wild type brain.
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Abnormal Spatial Learning ADD2 (↓) AMPH (↓) ATP1A2 (↑) CTNND2 (↓) HCN1 (↓) MAPT (↓) NCAM1 (↓) PRKCG (↓) SHANK2 (↓) SHANK3 (↓) SLC24A2 (↓) SLC8A2 (↓) Abnormal Long Term Object Recognition Memory BRAF (↓) CCDC88A (↓) MAPT (↓) SHANK3 (↓) Abnormal Contextual Conditioning Behavior ADD2 (↓) AMPH (↓) CTNND2 (↓) MAP2 (↓) MAPT (↓) PRKCG (↓) |
Abnormal Motor Learning HCN1 (↓) MAPT (↓) SHANK3 (↓) SLC24A2 (↓) Reduced Long Term Potentiation ADD2 (↓) CCDC88A (↓) CTNNB1 (↑) MAPT (↓) PRKCG (↓) SHANK2 (↓) SHANK3 (↓) SLC24A2 (↓) Abnormal Long Term Depression SHANK3 (↓) SLC24A2 (↓) SLC8A2 (↓) Abnormal Cerebellum Morphology ATP2B2 (↓) CIT (↓) MAP1B (↑↓) MYO5A (↓) NCAM1 (↓) |
Impaired Ability to Fire Action Potentials KCNA2 (↓) KCNMA1 (↓) MADD (↑) Increased Synaptic Depression KCNMA1 (↓) SYN1 (↓) SYT1 (↑) Abnormal Neuron Physiology HCN2 (↓) KCNQ2 (↓) SHANK3 (↓) SLC8A2 (↓) SYT1 (↑) Abnormal Axon Morphology ANK2 (↓) DST (↓) GAP43 (↓) MAP1B (↑↓) MAPT (↓) NEFH (↑) PLEC (↓) |
Abnormal Neurotransmitter Secretion STXBP1 (↓) SYN1 (↓) SYT1 (↑) Abnormal Synaptic Vesicle Number BSN (↓) DNAJC6 (↓) KIF1A (↓) MADD (↑) MAP6 (↓) PCDH17 (↓) Abnormal Synaptic Vesicle Recycling AMPH (↓) DNAJC6 (↓) SYN1 (↓) Abnormal Excitatory Postsynaptic Currents CCDC88A (↓) MADD (↑) PRKCG (↓) SHANK3 (↓) SLC1A3 (↓) SYT1 (↑) |
Abnormal Synaptic Vesicle Clustering CTNNB1 (↑) KIF1A (↓) SYN1 (↓) Abnormal Synaptic Transmission BSN (↓) SHANK3 (↓) STXBP1 (↓) SYT1 (↑) Abnormal Nervous System Electrophysiology ATP1A2 (↑) HCN1 (↓) HCN2 (↓) KCNA2 (↓) PLCL1 (↓) Axon Degeneration DST (↓) KIF1A (↓) NEFH (↑) STXBP1 (↓) |
Phosphoproteins were grouped by the GeneAnalytics (LifeMap Sciences) software and are shown based on involvement in brain processes pertinent to cognition.
↑ or ↓ indicate an increase or decrease, respectively, in the phosphopeptide abundance.
Proteins in bold are those with 2 or more phosphopeptides with differential abundance in the Cyp46a1-/- brain as compared to the wild type brain.
Reference
- 1.Mast N, Lin JB, Anderson KW, Bjorkhem I, Pikuleva IA (2017) Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1). PLoS ONE 12(10): e0187168 https://doi.org/10.1371/journal.pone.0187168 [DOI] [PMC free article] [PubMed] [Google Scholar]