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. 2017 Dec 26;137(1):57–70. doi: 10.1161/CIRCULATIONAHA.117.028911

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© 2017 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Excitation-contraction coupling in Runx1^Δ/Δ mice 2 weeks after myocardial infarction (MI). A, Protocol, (B) typical calcium (Ca²⁺) transients, and (C) cell shortening. Mean Ca²⁺ transient: (D) peak, (E) minimum, and (F) amplitude (Runx1^fl/fl MI [n=25 cardiomyocytes, n=3 hearts], Runx1^wt/wt MI [n=28 cardiomyocytes, n=4 hearts], Runx1^Δ/Δ MI [n=28 cardiomyocytes, n=3 hearts]). *P<0.05, Runx1^Δ/Δ MI vs. Runx1^fl/fl MI and Runx1^wt/wt MI combined, linear mixed modeling. G, Mean time constant of Ca²⁺ transient decay. H, Mean caffeine-induced Ca²⁺ transient amplitude. I, Mean time constant of decay for caffeine-induced Ca²⁺ transient amplitude. J, Mean sarcoendoplasmic reticulum calcium transport ATPase (SERCA) activity. K, Mean fractional shortening (Runx1^fl/fl MI [n=27 cardiomyocytes, n=3 hearts], Runx1^wt/wt MI [n=27 cardiomyocytes, n=4 hearts], Runx1^Δ/Δ MI [n=23 cardiomyocytes, n=3 hearts]). L, Ca²⁺ transients from cardiomyocytes transduced with enhanced green fluorescent protein (Ad-GFP) or Ad-Runx1. M, Mean Ca²⁺ transient peak; Ad-GFP (n=16 cardiomyocytes, n=6 hearts) and Ad-Runx1 (n=22 cardiomyocytes, n=6 hearts). *P<0.05, linear mixed modeling. N, Caffeine-induced Ca²⁺ transient amplitude, Ad-GFP (n=13 cardiomyocytes, n=6 hearts), and Ad-Runx1 (n=19 cardiomyocytes, n=6 hearts). *P<0.05, linear mixed modeling.