Figure 2.

Change in serum creatinine (A) and plasma methotrexate (B) concentrations relative to the start of the high‐dose methotrexate infusion (time 0) in pediatric patients with acute lymphoblastic leukemia (ALL) receiving 5 g/m² over 24 hours on the Nordic Society of Paediatric Haematology and Oncology ALL‐2008 protocol who also received GP. Their measurements prior to glucarpidase (blue) and after glucarpidase (green) are shown relative to the predicted mean and 95% CI for patients receiving the same MTX dose (orange lines).

Abbreviations: CI, confidence interval; GP, glucarpidase; HPLC, high pressure liquid chromatography; MTX, methotrexate.