Table 1.
Baseline characteristics by baseline quintiles of diastolic blood pressure (N=9361)
| 1st quintile | 2nd quintile | 3rd quintile | 4th quintile | 5th quintile | |
|---|---|---|---|---|---|
| < 68 mm Hg | 68 – 74 | 75 – 80 | 81 – 87 | ≥ 88 | |
| (N=1749) | (N=1874) | (N=1816) | (N=1934) | (N=1988) | |
| Diastolic blood pressure, (mmHg) | 61 ± 5 | 71 ± 2 | 78 ± 2 | 84 ± 2 | 95 ± 6 |
| Age, (year) | 74.7 ± 8.2 | 70.3 ± 8.8 | 68.0 ± 8.5 | 65.2 ± 8.3 | 62.3 ± 8.3 |
| Female sex, (%) | 39.5 | 36.0 | 35.8 | 32.3 | 34.9 |
| Black race, (%) | 23.2 | 25.1 | 29.7 | 33.6 | 44.4 |
| History of cardiovascular disease, (%) | 29.1 | 24.1 | 18.0 | 15.3 | 14.9 |
| Chronic kidney disease, (%) | 42.3 | 29.8 | 27.6 | 23.2 | 20.1 |
| Framingham 10-year CVD risk score ≥15%, (%) | 60.3 | 59.5 | 60.3 | 60.8 | 67.2 |
| Never smoked, (%) | 43.2 | 43.6 | 45.5 | 44.6 | 43.3 |
| Antihypertensive agents, (no./patient) | 2.1 ± 1.0 | 1.9 ± 1.0 | 1.8 ± 1.0 | 1.7 ± 1.0 | 1.6 ± 1.1 |
| Systolic blood pressure, (mmHg)* | 131 ± 15 | 134 ± 13 | 138 ± 13 | 142 ± 13 | 152 ± 15 |
| Pulse pressure, (mmHg) | 70 ± 15 | 63 ± 14 | 61 ± 13 | 58 ± 13 | 57 ± 13 |
| Mean arterial pressure, (mmHg) | 85 ± 6 | 92 ± 5 | 98 ± 5 | 103 ± 5 | 114 ± 8 |
| Body-mass index, (kg/m2) | 28.3 ± 5.3 | 29.4 ± 5.7 | 30.0 ± 5.7 | 30.5 ± 5.8 | 30.8 ± 6.0 |
| Estimated GFR, (ml/min/1.73 m2) | 65 ± 20 | 70 ± 20 | 72 ± 20 | 75 ± 20 | 76 ± 21 |
| Urine ACR, (mg/g) | 10.7 (6.2,24.8) | 9.4 (5.6,20.3) | 8.5 (5.2,18.7) | 8.9 (5.4,20.5) | 10.2 (6.1,24.6) |
Results are presented as percents for binary variables and as mean ± SDs for continuous variables other than ACR or as median (interquartile range) for ACR.
*
Systolic blood pressure at screening visit was used to determine trial eligibility. Baseline visit values are presented in this table.
For comparison of differences between the quintiles, all p values <0.001, except for “never smoked” (p=0.57). CVD = cardiovascular disease; ACR = albumin-to-creatinine ratio; GFR = glomerular filtration rate.