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. Author manuscript; available in PMC: 2018 Oct 17.
Published in final edited form as: Biochemistry. 2017 Oct 3;56(41):5476–5480. doi: 10.1021/acs.biochem.7b00795

Figure 3.

Figure 3

SNP in CYP2C9 *3 and its influence on substrate binding. Overlay of CYP2C9 WT (yellow) and *3 (orange) complexed with losartan. The effect of distal I359L is transduced to the neighboring I-helix residues. The Y308 sidechain is displaced by >3 Å (black dashes), subsequently affecting the β4 loop crucial for substrate interaction near the active site. Losartans shown as spheres are numbered in red. Part of the protein image isomitted for clarity.