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. 2017 Jun 9;158(9):1765–1779. doi: 10.1097/j.pain.0000000000000971

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — Analyses of previously validated and predicted targets for miR-34c-5p. (A) Change in the expression of Prex2, one of the previously validated targets for miR-34c-5p in DRGs isolated from tumor-bearing mice as compared to sham controls (dark colored bar) or in sensory neurons transfected with a miR-3c-5p specific inhibitor as compared to scramble-inhibitor transfected controls (light colored bar). (B) Venn diagram representation of predicted targets for miR-34c-5p by 6 different target prediction algorithms. The number of genes consistently predicted as targets for miR-34c-5p by all programs is highlighted in a green circle. (C, D) Pie-chart representation of significantly enriched (Adj. P ≤ 0.05 calculated by the multiple test adjustment method as compared to number of reference genes in the category genome-wide) molecular function (C) and cellular component (D) Gene ontology terms by unique genes from the list of 1533 genes commonly predicted as targets for miR-34c-5p by 6 independent algorithms. (E) Annotation details for 4 genes prioritized as putative targets for miR-34c-5p in sensory neurons.