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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Biomaterials. 2017 Sep 17;148:16–30. doi: 10.1016/j.biomaterials.2017.09.017

Fig. 6. Mechanism of utilizing AC-NPs for improving cancer immunotherapy.

Fig. 6

Radiation of the primary tumor induces antigen release. Intratumorally administered AC-NPs bind with tumor antigens and improve their presentation to DCs. The improved immune activation combined with anti-PD-1 treatment eradicates the unirradiated secondary tumor. Adapted by permission from Macmillan Publishers Ltd: [Nature Nanotechnology] [148], copyright (2017).