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. 2017 Nov 22;8(67):111119–111129. doi: 10.18632/oncotarget.22630

Table 1. Pathway analysis for candidate genes conferring susceptibility to RA.

Pathway P value Genes
Based on genes identified in comparison of RA patients and controls
ECM-receptor interaction 2.1 x 10-3 COL4A4, COL6A5, COL11A1, COL11A2, HSPG2, ITGB5, LAMC1, THBS1
Protein digestion and absorption 2.3 x 10-3 ATP1A1, ATP1A4, COL4A4, COL6A5, COL11A1, COL11A2, MME, PRCP
Focal adhesion 2.8 x 10-2 RASGRF1, COL4A4, COL6A5, COL11A1, COL11A2, FLNB, ITGB5, LAMC1, MYL5, THBS1
Glycerophospholipid metabolism 4.8 x 10-2 CHAT, GPAT4, LPIN3, LPCAT1, MBOAT1, PTDSS2
Based on genes only identified in disease duration comparison of RA patients
Olfactory transduction 1.2 x 10-2 OR14C36, OR4A15, OR52N4, OR6C74, OR6C75, OR7G3, OR9K2