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. 2017 Dec 4;8(67):111728–111741. doi: 10.18632/oncotarget.22904

Figure 4. Inhibition of STAT3 activity and modulation of STAT3 translocation into the nucleus by fluspirilene.

Figure 4

(A) Changes in the levels of STAT3 phosphorylated at serine 727 residue [p-STAT3 (S727)] and total STAT3 were analyzed by western blotting in GSCs and GBM cells following the treatment with fluspirilene for 48 h. β-actin was used as a loading control. The bar graphs below the blots show relative levels of p-STAT3 (S727) quantified by densitometry and normalized to those of total STAT3. (B) Nuclear content of STAT3 reduced in GBM cell after 1.5 µM of fluspirilene treatment. STAT3 (red), DAPI (blue). Scale bar 100μm.