Table 1. The miRNAs having a different plasma expression level in lung cancer patients vs. cancer-free smokers of a development cohort.

miRNAs	P-value	AUC (95% CI)	Sensitivity	Specificity
miR-422a	0.0319	0.5328 (0.4180 to 0.6476)	52.38	66.00
miR-326	0.0130	0.6236 (0.5312 to 0.7710)	61.11	62.96
miR-324-3p	0.0063	0.6825 (0.5772 to 0.7879)	63.49	66.67
miR-103a-3p	0.0109	0.6450 (0.5340 to 0.7559)	58.73	60.00
miR-30a-5p	0.0350	0.5815 (0.4752 to 0.7078)	57.14	60.00
miR-1285	0.0025	0.7380 (0.6252 to 0.8510)	66.67	66.67
miR-1254	0.0017	0.7068 (0.6516 to 0.8701)	71.73	70.00
miR-574-5p	0.0122	0.5921 (0.4786 to 0.7055)	50.79	53.33
miR-146b-5p	0.0210	0.6439 (0.5306 to 0.7572)	58.49	60.00
miR-27a-3p	0.0164	0.6344 (0.5227 to 0.7461)	57.14	73.33
miR-27b-3p	0.0286	0.5630 (0.4445 to 0.6815)	50.70	50.00
miR-222-3p	0.0152	0.6000 (0.4874 to 0.7126)	55.56	56.67
miR-106a-3p	0.0331	0.6587 (0.5497 to 0.7677)	60.32	66.67
miR-92a-3p	0.0012	0.7899 (0.7003 to 0.8796)	71.43	86.87
miR-29c	0.0040	0.6804 (0.5740 to 0.7868)	65.08	60.00
miR-24a-3p	0.0151	0.6619 (0.5538 to 0.7701)	60.32	60.00
miR-486-5p	0.0048	0.7957 (0.7066 to 0.8848)	70.97	83.33
miR-425-5p	0.0043	0.6529 (0.5445 to 0.7614)	60.32	70.00
miR-221-3p	0.0095	0.5758 (0.4616 to 0.6900)	57.14	51.72
miR-301a-3p	0.0138	0.6465 (0.5254 to 0.7654)	61.11	62.96
miR-148a	0.0253	0.6085 (0.4941 to 0.7228)	58.73	66.67
miR-148b	0.0197	0.5812 (0.4661 to 0.6963)	54.84	62.27
miR-193a-3p	0.0076	0.7111 (0.6016 to 0.8206)	68.25	66.67
miR-21	0.0370	0.5783 (0.4629 to 0.6937)	58.73	63.33
miR-19b-3p	0.0397	0.6619 (0.5520 to 0.7719)	68.25	63.33
miR-210-3p	0.0061	0.7254(0.6249 to 0.8259)	66.43	63.33
miR-145	0.0012	0.7233 (0.6198 to 0.82670)	71.43	71.33
miR-126-3p	0.0023	0.7767 (0.6736 to 0.8798)	71.43	73.33
miR-223-3p	0.0098	0.6000 (0.4874 to 0.7126)	53.97	56.67
miR-205-5p	0.0012	0.7268 (0.6099 to 0.8302)	71.43	71.33

Abbreviations: AUC, the area under receiver operating characteristic curve; CI, confidence interval.