Table 2. The comparison of the four-plasma miRNA signature and the panel of three miRNAs in a development cohort and a validation cohort.

	A development cohort		A validation cohort
	Sensitivity (95% CI)*	Specificity (95% CI)*	Sensitivity (95% CI)*	Specificity (95% CI)*
The four-plasma miRNA signature	91.56 (83.58 to 96.17)	96.23 (90.36% to 99.29%)	91.18 (76.32 to 98.14)	96.67 (82.78 to 99.92)
The panel of three miRNAs	75.46 (64.89 to 83.45)	85.26 (76.06% to 91.89%)	76.47 (58.83 to 89.25)	83.33 (65.28 to 94.36)

Abbreviations: CI, confidence interval.

^* P<0.05.