Table 4. Genotype and allele distribution among GDM patients and controls.
| Gene | Variants | Minor allele | Genotypes in GDM patients (N=278), N (%) |
Genotypes in controls (N=179), N (%) |
P* | ||||
|---|---|---|---|---|---|---|---|---|---|
| AA | AB | BB | AA | AB | BB | ||||
| MTNR1B | rs10830963 | G | 49 (17.6) | 133 (47.8) | 96 (34.5) | 17 (9.5) | 69 (38.4) | 93 (52.0) | 0.001 |
| rs1387153 | T | 43 (15.5) | 131 (47.1) | 104 (37.4) | 11 (6.1) | 75 41.9) | 93 (52.0) | 0.001 | |
| CDKAL1 | rs7754840 | C | 34 (12.2) | 128 (46.0) | 116 (41.7) | 13 (7.3) | 85 (47.5) | 81 (45.3) | 0.226 |
| GCK | rs1799884 | T | 12 (4.3) | 81 (29.1) | 185 (66.5) | 0 (0) | 37 (20.7) | 142 (79.3) | 0.001 |
| IRS1 | rs1801278 | T | 0 (0) | 21 (7.6) | 257 (92.4) | 0 (0) | 19 (10.6) | 160 (89.4) | 0.309 |
| KCNJ11 | rs5219 | T | 54 (19.4) | 122 (43.9) | 102 (36.7) | 31 (17.3) | 92 (51.4) | 56 (31.3) | 0.288 |
| IGF2BP2 | rs4402960 | T | 24 (8.6) | 134 (48.2) | 120 (43.2) | 26 (14.5) | 76 (42.5) | 77 (43.0) | 0.120 |
| TCF7L2 | rs7903146 | T | 13 (4.7) | 104 (37.4) | 161 (57.9) | 12 (6.7) | 63 (35.2) | 104 (58.1) | 0.617 |
| rs12255372** | T | 14 (5.1) | 93 (33.8) | 168 (61.1) | 10 (5.7) | 56 (31.8) | 110 (62.5) | 0.889 | |
| FTO** | rs9939609 | A | 60 (21.8) | 136 (49.5) | 79 (28.7) | 28 (15.9) | 87 (49.4) | 61 (34.7) | 0.208 |
| FTO*** | rs9939609 | A | 16 (31.4) | 19 (37.3) | 16 (31.4) | 1 (4.5) | 15 (68.2) | 6 (27.3) | 0.018 |
* P value of two-sided chi-squared test for comparison of genotypes between the GDM and control groups. ** - for this SNP, 451 women were genotyped (275 GDM patients and 176 controls), *** - counted for the group of women with high sausage consumption (>3/week, N=73).