Figure 3. Temperature changes with APC dose and tumor volume.

(A) The effect of APC dose (0, 10 or 100 μg) on temperature changes at a power density of 600 mW/cm² with air cooling. There were no significant differences among the tested groups. n = at least 5 in each group indicating little effect of APC dose. (B, C) Temperature increases at different tumor volumes (day 4, 6 and 8 cell incubation period) using laser irradiation at 600 mW/cm² with air cooling, and tumor volume in each group. There were no significant differences among them. n = at least 5 in each group. Data are means ± SEM. ^*P < 0.05 versus the other group. This indicates temperature changes are not dependent on tumor volume.