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Neurology: Clinical Practice logoLink to Neurology: Clinical Practice
letter
. 2015 Apr;5(2):92. doi: 10.1212/CPJ.0000000000000138

Blood pressure management in stroke

Five new things

Simona Lattanzi 1, Mauro Silvestrini 1
PMCID: PMC5764439  PMID: 29443193

We appreciated reading the article by Bowry et al.1 addressing the long-debated and controversial issue of management of blood pressure (BP) in stroke. The authors integrated different relevant aspects such as stroke subtype, eligibility for reperfusion therapy, cerebrovascular anatomy, and concurrent medical conditions to provide practical suggestions aimed at formulating a timely, effective strategy for BP control in both ischemic and hemorrhagic stroke.

Besides BP reduction at specific target goals, further efforts should also be undertaken to ensure stability of BP levels. BP variability has been increasingly recognized as a strong vascular risk factor and a predictor of stroke outcome independent of mean BP levels.24 In our opinion, greater attention should be paid to this new perspective because of the potential implications in clinical practice. First, continuous monitoring should be tailored to provide additional information on short- and long-term BP fluctuations. Second, physicians should not be falsely reassured by BP readings within “normal” ranges if high variability coexists. Finally, practitioners should be aware that BP stability may be affected by both the intensity of treatment and the type of antihypertensive agent.5

Disclosures:

The authors report no disclosures.

References

  • 1.Bowry R, Navalkele DD, Gonzales NR. Blood pressure management in stroke: Five new things. Neurol Clin Pract. 2014;4:419–426. doi: 10.1212/CPJ.0000000000000085. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Stead LG, Gilmore RM, Vedula KC, Weaver AL, Decker WW, Brown RD. Impact of acute blood pressure variability on ischemic stroke outcome. Neurology. 2006;66:1878–1881. doi: 10.1212/01.wnl.0000219628.78513.b5. [DOI] [PubMed] [Google Scholar]
  • 3.Manning L, Hirakawa Y, Arima H. Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial. Lancet Neurol. 2014;13:364–373. doi: 10.1016/S1474-4422(14)70018-3. [DOI] [PubMed] [Google Scholar]
  • 4.Delgado-Mederos R, Ribo M, Rovira A. Prognostic significance of blood pressure variability after thrombolysis in acute stroke. Neurology. 2008;71:552–558. doi: 10.1212/01.wnl.0000318294.36223.69. [DOI] [PubMed] [Google Scholar]
  • 5.Webb AJ, Fischer U, Mehta Z, Rothwell PM. Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet. 2010;375:906–915. doi: 10.1016/S0140-6736(10)60235-8. [DOI] [PubMed] [Google Scholar]
  • 6.Aslanyan S, Fazekas F, Weir CJ, Horner S, Lees KR. Effect of blood pressure during the acute period of ischemic stroke on stroke outcome: a tertiary analysis of the GAIN International Trial. Stroke. 2003;34:2420–2425. doi: 10.1161/01.STR.0000091233.04524.0C. [DOI] [PubMed] [Google Scholar]
Neurol Clin Pract. 2015 Apr;5(2):92.

Authors Respond:


Ritvij Bowry, MD, Digvijaya Navalkele, MD, MPH, Nicole Gonzales, MD: We appreciate and welcome the insightful comments set forth by Drs. Lattanzi and Silvestrini on our article.1 BP variability and its relation to clinical outcomes is an important clinical variable that cannot be emphasized enough,4,6 especially in light of recent evidence suggesting the same.

University of Texas Health Sciences Center, Houston.

Disclosures: R. Bowry and D. Navalkele report no disclosures. N. Gonzales serves as an editorial board member for Stroke and receives research support from the NIH/National Institute of Neurological Disorders and Stroke.


Articles from Neurology: Clinical Practice are provided here courtesy of American Academy of Neurology

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