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. 2017 Nov 28;8(69):113583–113597. doi: 10.18632/oncotarget.22745

Table 1. Correlation between clinicopathologic feature of patients and intensity of ARF6, NEDD9 and MT1-MMP.

Clinical Parameters Cores (%)
Tissues Grade Age (y) Tumor Cores Staining ARF6 NEDD9 MT1-MMP
Normal NA 37–72 NA 23 Low (1–2) 94.34 ± 0.11 95.45 ± 0.21 97.40 ± 0.21
High (3–4) 5.66 ± 0.18 4.55 ± 0.11 3.59 ± 0.27
Malignant Gr .I 36–57 T1. T2 60 Low (1–2) 25.56 ± 0.21 17.45 ± 0.32 20.23 ± 0.21
High (3–4) 74.44 ± 0.19 82.55 ± 0.19 79.77 ± 0.32
Gr .II 29–84 T1. T2 120 Low (1–2) 14.98 ± 0.22 10.56 ± 0.24 15.07 ± 0.27
High (3–4) 85.02 ± 0.15 89.03 ± 0.11 84.93 ± 0.19
Gr. III 45–80 T1. T2 T3. T4 34 Low (1–2) 10.78 ± 0.12 9.65 ± 0.13 11.30 ± 0.45
High (3–4) 89.22 ± 0.22 90.44 ± 0.18 88.68 ± 0.36

NOTE: Grade I, indicates well differentiated; Grade II, moderately differentiated; Grade III, poorly differentiated; T1, indicates tumor invades submucosa; T2, tumor invades muscularis propria; T3, tumor invades through muscularis propria into subserosa or into nonperitonealized pericolic or perirectal tissues; T4, tumor directly invades other organs or sturtures and/or perforate. Staining intensity: 0, no staining; 1, weak; 2, moderate; 3, strong. The percentage of cells expressing elevated levels of ARF6, NEDD9 and MT-MMP was high in endometrial tumors compared to normal endometrium. Statistically significant (p < 0.05) values are given in bold.