TABLE 3 .
Representative proteins dysregulated when AliC and AliD are absent from strain MNZ41
| NCBI accession no. |
Protein description | Protein function | Regulation direction in strain JLB01 |
P value |
|---|---|---|---|---|
| EPD18890.1 | Adenylate kinase | ADP synthesis using ATP and AMP | Up | 0.029 |
| EPD19581.1 | DNA protection during starvation protein |
Oxidative damage protectant | Up | 0.014 |
| EDP19576.1 | Endoribonuclease L-PSP | Translation initiation inhibitor | Up | 0.014 |
| EPD21090.1 | Acetaldehyde reductase | Regeneration of NAD+ | Up | 0.014 |
| EPD18727.1 | Glutamyl aminopeptidase | Glutamate synthesis | Down | P < 0.01 |
| EPD20852.1 | Asparagine synthetase AsnA | Asparagine synthesis | Down | P < 0.01 |
| EPD19911.1 | Aspartate kinase | Threonine synthesis from aspartate | Down | 0.012 |
| EPD22312.1 | IMP dehydrogenase | De novo synthesis of guanine nucleotides | Down | 0.013 |
| EPD21793.1 | Uracil ribosyltransferase | Pyrimidine (uracil) salvage | Down | 0.029 |
| EPD18378.1 | 6-Phosphofructokinase | Synthesis of fructose-1,6-bisphosphate in glycolysis | Down | P < 0.01 |
| EPD21778.1 | Pyruvate oxidase (SpxB) | Production of endogenous H2O2, pneumolysin release | Down | 0.014 |
| EPD16767.1 | GroEL | Refolding of misfolded proteins under stressful conditions |
Down | P < 0.01 |
| EPD19400.1 | DnaK | Chaperone; folding of nascent proteins and misfolded proteins during stress |
Down | 0.014 |
| EPD21629.1 | NADH oxidase | Protects against oxidative stress, aids in adherence | Down | 0.011 |
| EPD17685.1 | CbpAC (PspC variant) | Surface adhesion; binding to Fc IgA | Down | P < 0.01 |