Skip to main content
. 2017 Dec 15;8(70):115384–115397. doi: 10.18632/oncotarget.23266

Figure 4. Reverse effects of IL-22 at IRI and AR stages of allograft liver transplantation.

Figure 4

(A) Recipient rats (n=5) of the allograft group were treated with the indicated neutralizing antibodies by intravenous injection twice at 12 and 24 h prior to sacrifice at 1 day and 7 day post-transplantation, respectively. Plasma ALT levels, AST levels, and RAI scores were determined for the indicated groups at the indicated times. (B and C) Total protein was extracted from liver tissue and the expressions of IL-22, IL-22 R1, p-STAT3 and total STAT3 proteins at the indicated groups and time points were evaluated by Western blotting with β-actin as the internal control. (D) Bcl2, Bcl-xL and Cyclin D1 mRNA levels in liver tissues of recipients (n=5) in the indicated groups at days 1 and 7 after liver transplantation were evaluated by quantitative PCR. *p<0.05.