FIG 1 .

(A) Bacteriophage lytic cycle. 1, Adsorption of phage to the bacterium; 2, injection of genetic material into the cytoplasm; 3, replication of phage genetic material; 4, synthesis of phage components; 5, assembly of new phage particles; 6, bacterial lysis and release of phage particles. (B) Role of phage lytic proteins in the phage life cycle. VAPGHs favor the injection of phage genetic material into the cytoplasm by the formation of a hole in the cell wall. Endolysins and holins are produced at the end of the life cycle. Holins form a pore in the bacterial membrane, allowing the endolysin to reach the peptidoglycan.