Table 3. SCD1 inhibitor’s “druglikeness” for each candidate based # violations of to Lipinski’s Rule of 5 and Jorgensen’s Rule of 3.
Drug candidate Compound | Rule of 5 | Rule of 3 |
TC03.1 | 1 | 1 |
TC03.10 | 2 | 1 |
TC03.14 | 1 | 1 |
TC03.15 | 1 | 1 |
SSI-2‡ | 1 | 1 |
TC03.18 | 2 | 1 |
TC03.23 | 1 | 1 |
TC03.31 | 1 | 1 |
TC03.32 | 1 | 1 |
TC03.33 | 2 | 1 |
TC03.37 | 1 | 1 |
TC03.4 | 1 | 1 |
TC03.41 | 1 | 1 |
SSI-3‡ | 1 | 1 |
TC03.46 | 1 | 1 |
TC03.47 | 1 | 1 |
TC03.48 | 2 | 1 |
TC03.5 | 1 | 1 |
TC03.53 | 2 | 1 |
TC03.56 | 1 | 1 |
TC03.6 | 1 | 1 |
TC03.60 | 1 | 1 |
TC03.61 | 1 | 1 |
TC03.66 | 2 | 1 |
TC03.8 | 2 | 1 |
SetA.100 control | 0 | 1 |
SSI-4‡ | 0 | 0 |
SetA.59 | 0 | 0 |
SetA.61 | 0 | 0 |
SetA.68 | 0 | 0 |
SetA.69 | 0 | 0 |
SetA.70 | 0 | 0 |
SSI-1‡ | 0 | 1 |
SetB.34 | 0 | 1 |
SetB.49 | 0 | 0 |
SetB.52 | 0 | 1 |
SetB.6 | 0 | 1 |
SetB.61 | 0 | 1 |
SetB.66 | 0 | 1 |
SetB.69 | 0 | 1 |
SetB.7 | 0 | 1 |
SetB.73 | 0 | 1 |
SetB.74 | 0 | 0 |
SetB.75 | 0 | 0 |