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. 2017 Dec 11;9(1):783–790. doi: 10.18632/oncotarget.23153

Figure 5. Diagram illustrates the underlying mechanism of ESCCAL_1 knockdown inhibits tumor growth in nude mice.

Figure 5

From the phenotype of overexpression of ESCCAL_1 promoting tumor growth to targets screening of phospho-kinase protein array, along with shRNA knockdown of ESCCAL_1 expression, the cross-talk of multiple signaling pathways may participate in ESCCAL_1-mediated oncogenesis. The inactivation of p-Src, p-FAK, p-JNK1, decrease of Bcl-2 expression and increase of p-p38, p53, BAX and Caspase-3 expression in ESCCAL_1 KD group were detected in this study (Red arrows: decrease; white arrows: increase; black arrows: activate/induce).