Table 7. Different inheritance models analysis of rs12444338, rs4783244, rs12051272 and rs7195409 in CDH13 gene between I+II and III+IV pathologic stages (After adjusted for gender and age).
| SNPs | Models | Genotypes | I+II (n, %) | III+IV (n, %) | OR (95% CI) | P-value* | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
| rs12444338 | Codominant | G/G | 68 (46.6%) | 110 (35.7%) | 1.00 | 0.012 | 600.8 | 831.4 |
| G/T | 63 (43.1%) | 148 (48.0%) | 1.41 (0.87–2.30) | |||||
| T/T | 15 (10.3%) | 50 (16.2%) | 3.10 (1.41–6.82) | |||||
| Dominant | G/G | 68 (46.6%) | 110 (35.7%) | 1.00 | 0.031 | 603.0 | 829.5 | |
| G/T-T/T | 78 (53.4%) | 198 (64.3%) | 1.66 (1.05–2.65) | |||||
| Recessive | G/G-G/T | 131 (89.7%) | 258 (83.8%) | 1.00 | 0.009 | 600.7 | 827.2 | |
| T/T | 15 (10.3%) | 50 (16.2%) | 2.56 (1.22–5.38) | |||||
| Overdominant | G/G-T/T | 83 (56.9%) | 160 (52.0%) | 1.00 | 0.740 | 607.5 | 834.0 | |
| G/T | 63 (43.1%) | 148 (48.0%) | 1.08 (0.69–1.70) | |||||
| Log-additive | --- | --- | --- | 1.64 (1.16–2.31) | 0.004 | 599.5 | 826.0 | |
| rs4783244 | Codominant | G/G | 66 (45.2%) | 107 (34.7%) | 1.00 | 0.017 | 601.5 | 832.1 |
| T/G | 63 (43.1%) | 149 (48.4%) | 1.40 (0.86–2.29) | |||||
| T/T | 17 (11.6%) | 52 (16.9%) | 2.91 (1.35–6.30) | |||||
| Dominant | G/G | 66 (45.2%) | 107 (34.7%) | 1.00 | 0.037 | 603.3 | 829.8 | |
| T/G-T/T | 80 (54.8%) | 201 (65.3%) | 1.64 (1.03–2.62) | |||||
| Recessive | G/G-T/G | 129 (88.4%) | 256 (83.1%) | 1.00 | 0.012 | 601.3 | 827.8 | |
| T/T | 17 (11.6%) | 52 (16.9%) | 2.41 (1.17–4.97) | |||||
| Overdominant | G/G-T/T | 83 (56.9%) | 159 (51.6%) | 1.00 | 0.760 | 607.5 | 834.0 | |
| T/G | 63 (43.1%) | 149 (48.4%) | 1.07 (0.68–1.69) | |||||
| Log-additive | --- | --- | --- | 1.61 (1.14–2.27) | 0.006 | 600.0 | 826.5 | |
| rs12051272 | Codominant | G/G | 71 (48.6%) | 118 (38.3%) | 1.00 | 0.015 | 601.2 | 831.9 |
| G/T | 59 (40.4%) | 142 (46.1%) | 1.47 (0.91–2.38) | |||||
| T/T | 16 (11.0%) | 48 (15.6%) | 2.96 (1.34–6.51) | |||||
| Dominant | G/G | 71 (48.6%) | 118 (38.3%) | 1.00 | 0.024 | 602.5 | 829.0 | |
| G/T-T/T | 75 (51.4%) | 190 (61.7%) | 1.69 (1.07–2.69) | |||||
| Recessive | G/G-G/T | 130 (89.0%) | 260 (84.4%) | 1.00 | 0.015 | 601.7 | 828.2 | |
| T/T | 16 (11.0%) | 48 (15.6%) | 2.41 (1.14–5.08) | |||||
| Overdominant | G/G-T/T | 87 (59.6%) | 166 (53.9%) | 1.00 | 0.540 | 607.2 | 833.7 | |
| G/T | 59 (40.4%) | 142 (46.1%) | 1.15 (0.73–1.81) | |||||
| Log-additive | --- | --- | --- | 1.63 (1.15–2.30) | 0.005 | 599.6 | 826.1 | |
| rs7195409 | Codominant | A/A | 87 (60.0%) | 227 (73.7%) | 1.00 | 0.005 | 599.1 | 829.6 |
| A/G | 54 (37.2%) | 75 (24.4%) | 0.46 (0.28–0.75) | |||||
| G/G | 4 (2.8%) | 6 (2.0%) | 0.37 (0.09–1.64) | |||||
| Dominant | A/A | 87 (60.0%) | 227 (73.7%) | 1.00 | 0.001 | 597.2 | 823.6 | |
| A/G-G/G | 58 (40.0%) | 81 (26.3%) | 0.45 (0.28–0.73) | |||||
| Recessive | A/A-A/G | 141 (97.2%) | 302 (98.0%) | 1.00 | 0.360 | 606.8 | 833.2 | |
| G/G | 4 (2.8%) | 6 (2.0%) | 0.50 (0.12–2.16) | |||||
| Overdominant | A/A-G/G | 91 (62.8%) | 233 (75.7%) | 1.00 | 0.003 | 598.7 | 825.1 | |
| A/G | 54 (37.2%) | 75 (24.4%) | 0.48 (0.29–0.78) | |||||
| Log-additive | --- | --- | --- | 0.50 (0.32–0.77) | 0.002 | 597.6 | 823.9 |
*Statistical significant threshold was set at P < 0.007 (0.05/7) determined by Bonferroni correction.