Skip to main content
. 2017 Dec 23;10(1):2. doi: 10.3390/v10010002

Figure 3.

Figure 3

Protection of mice from lethal H5N1 virus challenge. Mice (n = 6/group) were subcutaneously immunized on days 0 and 28 with RG-H5N3 or RG-H5N3HAM1 or RG-H5N3HAM2 viral vaccine and PBS. Four weeks after the second vaccination, mice were intranasally infected with 5 50% mouse lethal dose (MLD50) of a clade 2.3.2.1 H5N1 (RG-A/Hubei/1/2010) strain on day 49. Mice were monitored for survival for 14 days and the results were expressed in percent survival (A). Weight loss of the mice groups was also monitored throughout the 14-day observation period and the results were expressed in percent body weight compared to the start of the viral challenge (B).