Table 1.
Therapeutics under investigation against respiratory syncytial virus and influenza viruses.
| Drug Name | Target | Reference(s) |
|---|---|---|
| RSV inhibitors | ||
| GS-5806 | RSV F protein | [102,103,104] |
| NMSO3 | RSV G protein | [105,106] |
| RSV 604 (benzodiazepine) | RSV N protein | [107,108] |
| VP-14637 | RSV F Protein | [109,110,111] |
| AZ-27 | RSV L protein | [112] |
| ALS-008176 | RSV L protein | [113,114] |
| Nitazoxanide | Pyruvate: ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction | [115] |
| IAV inhibitors | ||
| Nitazoxanide | HA protein | [115,116] |
| Favipiravir | RNA dependent RNA polymerase complex | [117,118] |
| VX-787 | PB2 protein | [119,120,121] |
| AL-794 | PA protein | [122] |
| Nucleozin | NP protein | [123,124] |
| DAS181 | Fusion inhibitor | [125,126,127] |
| Immunomodulatory drugs | ||
| Eritoran (E5564) | TLR4 antagonist | [128,129] |
| Rosiglitazone/pioglitazone | Peroxisome proliferator-activated receptor γ antagonist | [130] |
| Azithromycin (macrolides) | Interferon-augmenting | [131] |
Abbreviations: F: Fusion; G: Attachment; N: Nucleoprotein; L: Large Polymerase; HA: Hemagglutinin; PB2; RNA polymerase Basic 2; PA: Polymerase Acidic; NP: Nucleoprotein; TLR4: Toll-like Receptor 4.