Table 2. The association between physical activity and colorectal cancer risk stratified by gender and anatomical sites.
| Colorectal cancer | Colon cancer | Rectal cancer | |||||
|---|---|---|---|---|---|---|---|
| Control (%) | Case (%) | OR (95% CI)a | Case (%) | OR (95% CI)a | Case (%) | OR (95% CI)a | |
| All | |||||||
| Regular exercise | |||||||
| No | 753 (41.8) | 612 (66.3) | 1.00 | 299 (64.6) | 1.00 | 301 (67.8) | 1.00 |
| Yes | 1047 (58.2) | 311 (33.7) | 0.37 (0.30–0.45) | 164 (35.4) | 0.38 (0.30–0.49) | 143 (32.2) | 0.36 (0.28–0.46) |
| Physical activity (MET-min/week) | |||||||
| Low (<1059) | 612 (33.3) | 306 (33.2) | 1.00 | 152 (32.9) | 1.00 | 146 (33.0) | 1.00 |
| Moderate (1059-<2871) | 612 (33.3) | 366 (39.7) | 1.02 (0.81–1.29) | 186 (40.3) | 1.03 (0.78–1.36) | 175 (39.5) | 1.03 (0.77–1.37) |
| High (≥2871) | 613 (33.4) | 249 (27.0) | 0.62 (0.48–0.79) | 124 (26.8) | 0.63 (0.47–0.85) | 122 (27.5) | 0.63 (0.46–0.86) |
| p-trend | <0.001 | 0.001 | <0.001 | ||||
| Male | |||||||
| Regular exercise | |||||||
| No | 489 (40.6) | 387 (61.9) | 1.00 | 175 (59.1) | 1.00 | 205 (64.1) | 1.00 |
| Yes | 716 (59.4) | 238 (38.1) | 0.45 (0.35–0.58) | 121 (40.9) | 0.48 (0.35–0.65) | 115 (35.9) | 0.44 (0.32–0.59) |
| Physical activity (MET-min/week) | |||||||
| Low (<1314) | 412 (33.2) | 215 (34.5) | 1.00 | 100 (33.9) | 1.00 | 110 (34.5) | 1.00 |
| Moderate (1314–<3390) | 415 (33.4) | 239 (38.4) | 0.81 (0.61–1.09) | 114 (33.4) | 0.80 (0.56–1.14) | 123 (38.6) | 0.83 (0.58–1.18) |
| High (≥3390) | 415 (33.4) | 169 (27.1) | 0.56 (0.41–0.76) | 81 (27.5) | 0.56 (0.38–0.82) | 86 (27.0) | 0.56 (0.39–0.83) |
| p-trend | <0.001 | 0.003 | 0.003 | ||||
| Female | |||||||
| Regular exercise | |||||||
| No | 264 (44.4) | 225 (75.5) | 1.00 | 124 (74.3) | 1.00 | 96 (77.4) | 1.00 |
| Yes | 331 (55.6) | 73 (24.5) | 0.26 (0.18–0.37) | 43 (25.8) | 0.27 (0.17–0.42) | 28 (22.6) | 0.24 (0.14–0.39) |
| Physical activity (MET-min/week) | |||||||
| Low (<735) | 198 (33.3) | 104 (34.9) | 1.00 | 63 (37.7) | 1.00 | 37 (29.8) | 1.00 |
| Moderate (735-<2128) | 198 (33.3) | 97 (32.6) | 0.85 (0.57–1.28) | 48 (28.7) | 0.67 (0.41–1.09) | 48 (38.7) | 1.23 (0.73–2.07) |
| High (≥2128) | 199 (33.5) | 97 (32.6) | 0.69 (0.46–1.05) | 56 (33.5) | 0.66 (0.41–1.06) | 39 (31.5) | 0.81 (0.47–1.40) |
| p-trend | 0.086 | 0.143 | 0.268 | ||||
aAdjusted for age, gender, marital status, occupation, income, education, BMI, smoking, alcohol, family history of CRC, total energy intake.