Table 1.
Characteristics of studied population including the distribution of FTO rs9939609 polymorphism genotypes stratified by recurrent and non-recurrent status
| Parameters | Non recurrent VTE n (%) |
Recurrent VTE n (%) |
Total n (%) |
¶P- value |
|---|---|---|---|---|
| FTO genotype rs9939609 | ||||
| TT | 375 (32.5) | 44 (29.9) | 419 (32.2) | |
| AT | 575 (49.9) | 70 (47.6) | 645 (49.6) | 0.352 |
| AA | 203 (17.6) | 33 (22.4) | 236 (18.2) | |
| TT and AT | 950 (82.4) | 114 (77.6) | 1064 (81.8) | 0.172 |
| AA | 203 (17.6) | 33 (22.4) | 236 (18.2) | |
| Age a inclusion | ||||
| Years, Median (IQR) | 66.4 (24) | 63.4 (24) | 65.8 (24) | 0.088† |
| BMI | ||||
| Mean±SD | 26.6±4.7 | 27.4±5.1 | 26.6±4.8 | 0.066* |
| Sex | ||||
| Male | 565 (48.6) | 78 (52.7) | 643 (49.0) | 0.383 |
| Female | 598 (51.4) | 70 (47.3) | 668 (51.0) | |
| DVT+PE | ||||
| DVT | 736(68.2) | 98 (68.5) | 834 (68.2) | 0.323 |
| PE | 277 (25.7) | 32 (22.4) | 309 (25.3) | |
| DVT+PE | 66 (6.1) | 13 (9.1) | 79 (6.5) | |
| Thrombophilia | ||||
| Yes | 390 (36.9) | 68 (49.6) | 458 (38.3) | 0.005 |
| No | 668 (63.1) | 69 (50.4) | 737 (61.7) | |
| Family history | ||||
| Yes | 269 (23.5) | 47 (32.4) | 316 (24.5) | 0.024 |
| No | 875 (76.5) | 98 (67.6) | 973 (75.5) |
DNA was not enough for genotyping in 11 samples for FTO rs9939609 polymorphism, DVT, deep vein thrombosis; PE, pulmonary embolism; BMI, body mass index. P-value, Chi square test until unless indicated,
*
Student T-test,
†
Mann-Whitney U test.
¶
comparing non-recurrent with recurrent VTE. IQR, Interquartile range. Thrombophilia, presence of factor V Leiden, factor II G20210A, or antithrombin, protein C or free protein S levels below the laboratory reference ranges.