Table 3.
Univariable and multivariable analysis of patient, tumor, and treatment characteristics and their association with overall survival in patients 80 years and older with stage III non-small cell lung cancer.
| Univariable Analysis | Multivariable Analysis* | ||||
|---|---|---|---|---|---|
| Covariate | Level | Hazard Ratio (95% CI) |
P-value | Hazard Ratio (95% CI) |
P-value |
| Patient Characteristics | |||||
| Age at Diagnosis | 1.05 (1.04–1.06) | <0.01 | 1.02 (1.01–1.04) | <0.01 | |
| Race | Black | 0.98 (0.92–1.05) | 0.65 | 0.81 (0.73–0.90) | <0.01 |
| Other | 0.90 (0.81–0.99) | 0.03 | 0.94 (0.88–1.01) | 0.30 | |
| White | - | - | - | - | |
| Insurance Payer | Private and Medicare | 0.98 (0.92–1.05) | 0.62 | - | - |
| Medicare | - | - | - | - | |
| Sex | Male | 1.10 (1.04–1.16) | <0.01 | 1.16 (1.11–1.20) | <0.01 |
| Female | - | - | - | - | |
| Median Income of Patient’s County of Residence (dollars) | < $38,000 | 1.04 (0.98–1.10) | 0.18 | - | - |
| $38,000 – $47,999 | 1.02 (0.97–1.08) | 0.33 | - | - | |
| $48,000 – $62,999 | 1.02 (0.97–1.07) | 0.41 | - | - | |
| $63,000 + | - | - | - | - | |
| Percentage of County of Residence without a High-School Degree | ≥ 21% | 1.09 (0.99–1.19) | 0.06 | 1.03 (0.97–1.10) | 0.28 |
| 13–20% | 1.04 (0.96–1.13) | 0.36 | 1.01 (0.96–1.06) | 0.84 | |
| 7–12.9% | 1.08 (0.99–1.17) | 0.06 | 1.07 (1.00–1.13) | 0.06 | |
| < 7% | - | - | - | - | |
| County Type | Rural | 1.07 (0.93–1.24) | 0.33 | - | - |
| Urban | 1.00 (0.95–1.06) | 0.89 | - | - | |
| Metro | - | - | - | - | |
| Charlson-Deyo Comorbidity Score | 0 | 0.87 (0.82–0.92) | <0.01 | 0.81 (0.78–0.84) | <0.01 |
| 1+ | - | - | - | - | |
| Tumor Characteristics | |||||
| Histology | Non-Small Cell Lung Cancer (NOS) | 1.12 (1.05–1.21) | 0.01 | 1.14 (1.09–1.20) | <0.01 |
| Squamous Cell Carcinoma | 1.11 (1.04–1.18) | <0.01 | 1.07 (1.02–1.12) | <0.01 | |
| Adenocarcinoma | - | - | - | - | |
| Histological Grade | Moderately Differentiated | 1.33 (1.13–1.57) | <0.01 | 1.42 (1.25–1.61) | <0.01 |
| Poorly Differentiated | 1.28 (1.09–1.49) | <0.01 | 1.55 (1.37–1.75) | <0.01 | |
| Well Differentiated | - | - | |||
| Clinical Stage Group | IIIB | 1.19 (1.12–1.25) | <0.01 | 1.35 (1.30–1.40) | <0.01 |
| IIIA | - | - | - | - | |
| Treatment Characteristics | |||||
| Treatment Type | No Treatment | 2.73 (2.61–2.85) | <0.01 | 2.69 (2.57–2.82) | <0.01 |
| Definitive Radiation Alone | 1.15 (1.07–1.23) | <0.01 | 1.15 (1.07–1.24) | <0.01 | |
| Concurrent Chemoradiation | - | - | |||
| Facility Type | Comprehensive Community Cancer Program | 0.98 (0.93–1.02) | 0.27 | 0.98 (0.94–1.03) | 0.41 |
| Academic Program | 0.86 (0.82–0.91) | <0.01 | 0.89 (0.85–0.94) | <0.01 | |
| Community Cancer Program | - | - | |||
| Facility Location | Northeast | 0.96 (0.90–1.02) | 0.16 | 1.03 (0.97–1.10) | 0.35 |
| South | 1.03 (0.98–1.09) | 0.23 | 1.08 (1.00–1.15) | 0.06 | |
| Midwest | 1.01 (0.96–1.07) | 0.65 | 1.11 (1.05–1.18) | <0.01 | |
| West | - | - | - | - | |
Key:
NOS – Not otherwise specified
Bold indicates statistical significance.
*
Variables were subjected to backwards elimination using an alpha cutoff of 0.1 for inclusion into the multivariable model. The same 484 patients did not have information on their census tract’s income or education, only one of these variables could be included in the multivariable model, but neither were significant on backwards elimination for inclusion in this multivariable model.