Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 2;7:141. [Version 1] doi: 10.12688/f1000research.12833.1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2018 Nye J et al.

This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions.

PMC Copyright notice

Figure 1. — The histone variant H3.3 relies on three specific chaperones for deposition at specific locations in the genome. The chaperones DEK, DAXX/ATRX, and HIRA have been shown to prefer distinct sites for H3.3 assembly. Furthermore, they have been found to be mis-regulated in many cancer types, as shown. The centromeric histone variant CENP-A normally associates with a single chaperone called HJURP. However, changes in the amount of CENP-A compared to its chaperone can allow for deposition throughout chromosome arms by the H3.3 chaperone DAXX.