Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
FoxO1 is required for the hyperleptinemia observed in LIRKO mice. Male mice were euthanized at 8 to 10 weeks of age. (a) Leptin and (b) the soluble leptin receptor were measured by ELISA in the plasma, and (c–e) gene expression was measured by real-time PCR in the liver. Error bars represent SEM; n = 6 to 10. *P < 0.05 vs control mice; #P < 0.05 LIRKO vs LDKO; $P < 0.05 LFKO vs LDKO. ObRa, ObRb, and ObRe, leptin receptor isoforms.
